for two things to be completely different from each other
to have nothing in common with someone or something else
to lack similarity when compared with someone or something
Despite James and John being identical twins, their characters were as different as chalk and cheese.
What he does in public and how in acts in private are as different as chalk and cheese.
Aside their names, the two teachers had nothing in common and could be said to be as different as chalk and cheese.
England in the Summer and England in the Winter are as different as chalk and cheese.
It’s safe to say that Lisa’s night job and her day job are as different as chalk and cheese.
There is no origin for this idiom
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definition
Common phrase that has a specific meaning.